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. 2022 Feb 3;11(3):528. doi: 10.3390/cells11030528

Figure 1.

Figure 1

GPCR superfamily A–F classification. GPCRs are around 800 proteins divided into seven different classes, namely class A (pink), class B (blue), class C (green), class D (yellow), class E (yellow) and class F (red). Classes A–C and F contain GPCRs expressed in mammalian systems, while classes D and E contain GPCRs expressed only in fungi and other non-vertebrate systems. The average number of receptors for each class in the mammalian system is shown in the dendrogram chart. Here, we highlight some of the GPCR families belonging to each specific class and their physiological role.