Figure 2.

Non-vesicular transport of lipids at the TGN. (a) LTPs acting at the ER-TGN MCSs transfer the indicated lipids from the ER to TGN, where they can be further metabolized as in the case of ceramide which is converted to Sphingomyelin. (b) A mutation in CERT hyperactivates it, thus increasing the production of Sphingomyelin, which is associated with intellectual disability. (c) CERT alteration in triple negative breast cancer cells reduces its activity and hence Sphingomyelin production, which leads to a cascade of events culminating in increased PI3K/Akt activation.