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. 2022 Jan 19;11(3):325. doi: 10.3390/cells11030325

Figure 1.

Figure 1

Th1, Th2, Th17, and Treg T CD4+ subset cells. Master transcription factors promoting Th polarization are reported inside cells (T-bet, GATA3, RORγT and Foxp3 for Th1, Th2, Th17, and Treg cell, respectively) together with selective secreted cytokines (γ-IFN, IL-4, IL-17 and IL-10 for Th1, Th2, Th17, and Treg cell, respectively). The main cytokines (IL-2, IL-4, IL-6, IL-12, IL-10, IL-21, IFN-γ, and TGF-1β) regulating Th polarization are reported: IL-10, secreted by Treg, acts as major inhibiting factors of Th polarization and proliferation.