The Heliconius pigmentation gene regulatory network subcircuit. (A) Wings of H. melpomene malleti (left) and H. erato emma (right) reveal their color pattern mimicry. (B) Proposed Heliconius pigmentation GRN; see text for details. The three subcircuits (grey boxes) in the pigmentation tier (bottom) are the yellow/white subcircuit, the black subcircuit, and the red subcircuit. The scale identity tier (middle) has two main subcircuits that have been identified, the Type I subcircuit (yellow box) and Type II/III subcircuit (red box). The top tier of the GRN specifies the presumptive scale cells (upper grey box). Regulation by upstream factors is hypothesized based on existing genetic data; direct TF-CRM relationships remain to be established. Arrows indicate activation and bars, repression. Image credit: panel A, © Wallbank et al. [56], used with permission under CC-BY 4.0 license.