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Leave-one-out cross-validation analysis of the prediction of HR for OS based on HR for PFS/TTP. Green circles represent predicted hazard ratio for OS, vertical lines for 95% prediction intervals, and blue squares for observed hazard ratios for OS. Red circles and lines indicate that the observed HR is beyond the 95% prediction intervals. HR, hazard ratio; OS, overall survival; PFS/TTP, progression-free survival/time to progression.
