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. 2022 Jan 26;11(3):420. doi: 10.3390/cells11030420

Figure 1.

Figure 1

The three stages of early limb bud development. (1) In the initial outgrowth stage, a bulge is formed in the lateral plate mesoderm. (2) This bulge elongates in the proximodistal direction and widens to form a paddle shape. (3) Simultaneously with the elongation, condensing zones are formed which will eventually form musculoskeletal elements of the limb.