Figure 8.

ZIP8-associated dysbiosis increases pulmonary and intestinal epithelial damage post S. pneumoniae infection. Mice recolonized with the cecal microbial community from WT and Zip8KO mice were infected with S. pneumoniae and the levels of circulating SPD-1 and IFABP were assessed. Circulating levels of (A) SPD-1 and (B) IFABP in mice recolonized with the cecal microbial community from WT and Zip8KO mice. Bars represent the mean ± SEM and dots represent individual mice. p values are indicated in the figure and were determined by one-way ANOVA with Sidak’s multiple comparison test. n = 6–12/group, 5–3/experimental replicates.