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. 2022 Jan 18;23(3):1022. doi: 10.3390/ijms23031022

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ZIP8-associated microbial products suppress macrophage cytokine production. Microbial products derived from the cecal microbial community from WT and Zip8KO mice were co-cultured with mouse MH-S macrophages for 6 or 24 h and macrophage viability and cytokine production was assessed. (A) Cytotoxicity of microbial products on MH-S cells. (B) IL-6 levels in the MH-S supernatant following co-culture with microbial products. (C) TNF-α levels in the MH-S supernatant following co-culture with microbial products. Bars represent the mean ± SEM and dots represent individual mice. p values are indicated in the figure and were determined by one-way ANOVA with Sidak’s multiple comparison test. n = 6/group, 3/experimental replicates.