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. 2022 Jan 20;23(3):1118. doi: 10.3390/ijms23031118

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of E2 on mitochondrial dynamics in pathologies of the nervous system. E2-associated signalling via its receptors or drugs that promote E2 production lead to the attenuation of fission and the promotion of fusion. Abbreviations: Aβ: amyloid-beta protein, Akap1: activates kinase anchoring protein 1, Drp1: dynamin-related protein 1, E2: 17β-Oestradiol, ERβ: oestrogen receptor β, Fis1: fission factor 1, Mfn1: mitofusin 1, Mfn2: mitofusin 2, MPTP: mitochondria permeability transition pore, Opa1: optic atrophy 1, Pka: protein kinase A and Sod: sodium oxide dismutase.