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. 2022 Jan 20;23(3):1109. doi: 10.3390/ijms23031109

Table 3.

The therapeutic role of miRNAs in PanNETs.

miRNA Expression Model Treatment Outcomes Ref. No.
miR-214 ⬆ Mouse miR-214 inhibition -Reduced tumor volume
-Decreased volume of peripancreatic lymphatic metastases
-Reduced tumor vascularization		 [134]
miR-431 ⬆ Cell lines miR-431-targeted locked nucleic acids -Reduced invasiveness [135]
miR-224 ⬇ Cell lines miR-224 agomir -Promotes apoptosis
-Inhibits proliferation, invasion		 [136]