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. 2022 Jan 28;12:813703. doi: 10.3389/fphar.2021.813703

TABLE 1.

Several molecular target and therapeutic role of different drugs in autophagy modulation in gastric cancer cells.

Compounds Experimental model Autophagy mechanism References
Chloroquine Bone marrow stromal cells Autophagy induction Lin et al. (2021a)
Nonsteroidal anti-inflammatory drugs SGC-7901 cells Autophagy induction Fletcher et al. (2021)
3-Methylalanine SGC-7901 cells Class III PI3K inhibitor and suppresses autophagy Li et al. (2013)
Bafilomycin A1 (BAF-1) MGC-803 cells Autophagy induction Bai et al. (2018)
β2-Adrenergic receptor Human SGC-7901 and BGC-823 cells AMPK-ULK1 mediated autophagy induction Zhi et al. (2019)
Indomethacin AGS cells Lysosomal-mediated autophagy induction Ahmed et al. (2021)
CXCL12 NUGC4 cell mTOR-mediated autophagy activation Mele et al. (2020)
Compound C AGS cells Inhibitory role of autophagy Li et al. (2013)
Rapamycin Human SGC-7901 and BGC-823 cells Induction of autophagy Chen et al. (2021b)