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. 2022 Jan 20;23(3):1095. doi: 10.3390/ijms23031095

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Proposed pathway for enhanced vascular disease mediated by high glucose -induced macrophage-derived exosomes through the up-regulation ofMALAT1, consequent suppression of miR-150-5p expression and up-regulation of resistin expression in macrophages. This pathway illustrates the critical role of macrophage-derived exosomal MALAT1 in vascular disease in diabetes mellitus. Therefore, macrophage-derived exosomal MALAT1 can serve as a valuable therapeutic target for vascular disease therapy in diabetes mellitus.