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Study design, showing the 72 h chemotherapeutics-induced mucositis (CIM) period (Table 1) and the 225 min single-pass perfusion period (75 min resting and 150 min experiment). The intestinal mannitol permeability was monitored during the whole 150 min experimental period. DOX- doxorubicin, 5-FU—5-Fluorouracil, IRI—irinotecan, SDS—sodium dodecyl sulfate, EtOH—Ethanol.
