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The four experimental groups according to the treatment received. See Figure 7 for details of the perfusion. SPIP—single-pass intestinal perfusion; SDS—sodium dodecyl sulfate.
| Intraperitoneal Dosing 72 h before SPIP |
SPIP Exposure Period (15 min) |
|---|---|
| Saline, control (n = 18) | Buffer (n = 6) |
| SDS 5 mg/mL (n = 6) | |
| Ethanol 15% w/w (n = 6) | |
| Doxorubicin 10 mg/kg (n = 12) or Irinotecan 150 mg/kg (n = 12) or 5-Fluorouracil 200 mg/kg (n = 12) |
SDS 5 mg/mL (n = 6) |
| Ethanol 15% w/w (n = 6) |
