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. 2022 Feb 8;19(3):1873. doi: 10.3390/ijerph19031873

Table 3.

Effect of 17-β Estradiol (E2) and Parabens on the Expression of Selected Genes in MCF-7 and MCF-10A [57].

MCF-7
Genes CCND1 CCND3 CCNE1 CCNE2 CCNA2 CDK2 CDK4 CDK6 CDKN1A ATR ATM E2F3 TP53
E2 ↑ ↑ NC ↑ ↑ ↑ ↑ ↓ ↑ ↑ ↓ ↓ NC
MP NC NC ↓ NC NC NC NC ↓ NC ↑ ↓ NC NC
PP NC NC ↑ NC NC ↑ NC ↓ NC ↑ ↓ ↓ NC
BP NC ↑ ↓ ↑ NC NC NC ↓ NC ↑ ↓ ↓ NC
MCF-10A
Genes CCND1 CCND3 CCNE1 CCNE2 CCNA2 CDK2 CDK4 CDK6 CDKN1A ATR ATM E2F3 TP53
E2 ↑ NC ↑ ↑ NC ↑ ↑ NC ↓ NC NC ↑ ↑
MP ↑ NC ↑ NC ↑ ↑ ↑ ↓ ↓ NC NC ↑ NC
PP ↑ ↓ ↑ NC ↑ ↑ ↑ NC ↓ NC ↑ ↑ ↑
BP ↑ ↓ ↑ ↑ ↑ ↑ ↑ ↑ ↓ ↑ ↑ ↑ NC

MCF-7 and MCF-10A cells were exposed to MP, BP, and PP (20 nM) or E2 (10 nM) for 24 hours. Up arrow: Upregulation of gene expression; down arrow: Downregulation of gene expression; NC: Non change.