Table 3.
MCF-7 | ||||||||||||||
Genes | CCND1 | CCND3 | CCNE1 | CCNE2 | CCNA2 | CDK2 | CDK4 | CDK6 | CDKN1A | ATR | ATM | E2F3 | TP53 | |
E2 | ↑ | ↑ | NC | ↑ | ↑ | ↑ | ↑ | ↓ | ↑ | ↑ | ↓ | ↓ | NC | |
MP | NC | NC | ↓ | NC | NC | NC | NC | ↓ | NC | ↑ | ↓ | NC | NC | |
PP | NC | NC | ↑ | NC | NC | ↑ | NC | ↓ | NC | ↑ | ↓ | ↓ | NC | |
BP | NC | ↑ | ↓ | ↑ | NC | NC | NC | ↓ | NC | ↑ | ↓ | ↓ | NC | |
MCF-10A | ||||||||||||||
Genes | CCND1 | CCND3 | CCNE1 | CCNE2 | CCNA2 | CDK2 | CDK4 | CDK6 | CDKN1A | ATR | ATM | E2F3 | TP53 | |
E2 | ↑ | NC | ↑ | ↑ | NC | ↑ | ↑ | NC | ↓ | NC | NC | ↑ | ↑ | |
MP | ↑ | NC | ↑ | NC | ↑ | ↑ | ↑ | ↓ | ↓ | NC | NC | ↑ | NC | |
PP | ↑ | ↓ | ↑ | NC | ↑ | ↑ | ↑ | NC | ↓ | NC | ↑ | ↑ | ↑ | |
BP | ↑ | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↓ | ↑ | ↑ | ↑ | NC |
MCF-7 and MCF-10A cells were exposed to MP, BP, and PP (20 nM) or E2 (10 nM) for 24 hours. Up arrow: Upregulation of gene expression; down arrow: Downregulation of gene expression; NC: Non change.