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. 2022 Jan 18;23(3):1025. doi: 10.3390/ijms23031025

Figure 2.

Figure 2

FLUDA (1 µM) inhibits the A2A-AR-dependent force of contraction (FOC) in isolated electrically driven left atria from A2A-AR transgenic mice (A2A-AR-TG) but not from wild-type mice (WT). (A) Exemplary original recordings of WT and A2A-AR-TG left atria. Control conditions (Ctr) are the inhibition of A1-adenosine receptors by 1 µM DPCPX and the degradation of extracellular adenosine by 1 µg/mL adenosine deaminase (ADA). Induction of atrial contraction was achieved by the A2A-AR agonist CGS 21680 (10 µM). (B) Quantification of left atrial force. Data are means ± SEM; numbers in columns are numbers of atrial preparations and + marks the added substance; * p < 0.05 vs. WT; + p < 0.05 vs. Ctr; # p < 0.05 vs. CGS (ANOVA).