Table 1.
Non-compartmental analysis of [18F]FLUDA showing the time to peak, the time-activity curve peak value (TAC peak value), the accumulated uptake from 0 to 60 min (AUC0–60), and from the initial 10 min (AUC1–10) p.i. in investigated tissues of the WT (n = 5) vs. A2A-AR TG (n = 6).
| Tissue | Time to Peak (min) |
TAC Peak Value (SUV) |
AUC0–60 (SUV·min) |
AUC1–10 (SUV·min) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | TG | p-Value | WT | TG | p-Value | WT | TG | p-Value | WT | TG | p-Value | |
| Myocardium | 0.6 ± 0.1 | 0.6 ± 0.0 | 0.105 | 6.3 ± 0.6 | 8.1 ± 0.7 | 0.0437 | 19.6 ± 2.0 | 35.0 ± 3.1 | 0.001 | 8.4 ± 0.9 | 19.3 ± 2.2 | < 0.001 |
| Blood | 0.7 ± 0.0 | 0.5 ± 0.0 | 0.011 | 6.9 ± 0.9 | 7.7 ± 0.7 | 0.242 | 20.4 ± 2.4 | 29.0 ± 1.8 | 0.008 | 8.6 ± 1.2 | 13.9 ± 1.1 | 0.004 |
| Muscle | 3.3 ± 1.0 | 4.0 ± 0.9 | 0.303 | 0.5 ± 0.1 | 0.5 ± 0.1 | 0.327 | 9.6 ± 1.4 | 12.1 ± 1.9 | 0.153 | 3.8 ± 0.5 | 4.7 ± 0.8 | 0.175 |
| Lung | 0.5 ± 0.1 | 0.5 ± 0.0 | 0.500 | 4.2 ± 0.4 | 4.7 ± 0.4 | 0.243 | 5.4 ± 0.5 | 17.8 ± 3.7 | 0.135 | 7.5 ± 0.7 | 7.3 ± 1.5 | 0.128 |
| Liver | 3.5 ± 0.5 | 5.1 ± 1.3 | 0.123 | 6.7 ± 1.1 | 6.1 ± 0.5 | 0.313 | 126 ± 17 | 143 ± 9 | 0.200 | 74.4 ± 9.3 | 61.5 ± 4.4 | 0.119 |
mean ± SEM; p-value—Student‘s t-Test.