Table 2.

Impact of pre-treatment with istradefylline (n = 3) on kinetic parameters in presented tissues of WT (n = 6) and A_2A-AR TG shown in % of control.

A2A-AR Group	Tissue	Time to Peak		TAC Peak Value		AUC0–60		AUC1–10
		Istradyfelline	p-Value	Istradyfelline	p-Value	Istradyfelline	p-Value	Istradyfelline	p-Value
WT	Myocardium	87 ± 9	0.175	130 ± 18	0.082	116 ± 4	0.166	87 ± 9	0.175
	Blood	75 ± 0	0.017	125 ± 11	0.125	117 ± 6	0.179	106 ± 6	0.381
	Muscle	44 ± 21	0.138	180 ± 24	0.027	119 ± 17	0.229	142 ± 19	0.061
	Lung	84 ± 11	0.223	109 ± 31	0.364	131 ± 32	0.130	133 ± 38	0.146
	Liver	100 ± 25	0.500	100 ± 11	0.499	83 ± 3	0.210	94 ± 5	0.410
TG	Myocardium	120 ± 17	0.107	91 ± 15	0.302	78 ± 8	0.083	61 ± 9	0.032
	Blood	105 ± 11	0.313	98 ± 9	0.442	100 ± 11	0.500	90 ± 9	0.222
	Muscle	58 ± 13	0.130	138 ± 50	0.211	84 ± 14	0.268	99 ± 21	0.483
	Lung	116 ± 11	0.090	95 ± 6	0.380	102 ± 2	0.470	92 ± 5	0.401
	Liver	54 ± 12	0.124	117 ± 3	0.090	95 ± 5	0.315	102 ± 0	0.431

mean ± SEM; p-value—Student‘s t-test.