Table 3.
Tissue uptake over time of [18F]FLUDA normalised to the left ventricle or the muscle in the initial phase from 1 to 10 min p.i. in the WT (n = 5) vs. A2A-AR TG group (n = 6).
| Treatment | Tissue | AUC1–10 Ratio (Tissue-to-Left Ventricle) | AUC1–10 Ratio (Tissue-to-Muscle) | ||||
|---|---|---|---|---|---|---|---|
| WT | A2A-AR TG | p-Value | WT | A2A-AR TG | p-Value | ||
| Vehicle | Myocardium | 1.0 ± 0.0 | 1.4 ± 0.1 | 0.001 | 2.4 ± 0.5 | 4.8 ± 1.2 | 0.028 |
| Lung | 0.7 ± 0.1 | 0.5 ± 0.1 | 0.081 | 1.5 ± 0.2 | 1.7 ± 0.2 | 0.297 | |
| Liver | 7.8 ± 1.0 | 6.0 ± 1.6 | 0.190 | 20.6 ± 2.8 | 16.5 ± 4.4 | 0.223 | |
| Myocardium | 1.0 ± 0.0 | 0.9 ± 0.1 | 0.570 | 1.8 ± 0.4 | 3.0 ± 1.1 | 0.334 | |
| Istradefylline | Lung | 0.8 ± 0.2 | 0.6 ± 0.1 | 0.400 | 1.3 ± 0.2 | 1.6 ± 0.3 | 0.483 |
| Liver | 6.5 ± 0.4 | 5.2 ± 0.8 | 0.193 | 11.5 ± 3.2 | 14.6 ± 2.7 | 0.390 | |
mean ± SEM; p-value—Student‘s t-test.