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. 2022 Jan 19;23(3):1083. doi: 10.3390/ijms23031083

Figure 5.

Figure 5

Amelioration of endotoxin-augmented mechanical ventilation-mediated HIF-1α and PHD2 protein expression in HIF-1α-deficient mice. Western blots were performed using antibodies that recognize HIF-1α (A), PHD2 (B), and GAPDH expression from the diaphragms of nonventilated control mice and mice ventilated at a tidal volume of 10 mL/kg for 8 h with or without LPS administration (n = 5 per group). Arbitrary units were expressed as relative HIF-1α and PHD2 activation (n = 5 per group). * p < 0.05 versus the nonventilated control mice with LPS treatment; † p < 0.05 versus all other groups. PHD2 = prolyl hydroxylase domain 2.