Figure 2.

Quantitative light microscopic microdensitometric analysis of CXCL10 protein expression in unchallenged and treated microglia-enriched cultures. The LPS challenge significantly elevated cytoplasmic CXCL10 immunoreactivity (approximately fourfold) in microglial cells, whereas KYNA alone, SZR104 alone, or the combined treatments significantly weakened the CXCL10 immunoreactive signal to levels observed in unchallenged (control) cells. LPS: 20 ng/mL; KYNA: 1 µM; and SZR104: 1 µM. Data (presented as means ± SEMs) were analyzed using Kruskal–Wallis one-way ANOVA on ranks: * p < 0.05.