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Schematic representation of a liposome with allocolchicinoid phospholipid prodrug (aC-PC) in the bilayer and matrix lipids used in the work, egg yolk-derived phosphatidylcholine (ePC, a representative structure is shown) and 1-palmitoyl-2-oleoylphosphatidylglycerol (POPG). The prodrug is subject to enzymatic hydrolysis by phospholipase A2 (PLA2) and non-specific esterases yielding the parent dihydrofuran allocolchicinoid (aC).
