Table 1.
Studied liposome compositions and their characteristics.
| Composition | Sample ID | ZP, mV * | Day 1 | Day 7 | Day 21 | |||
|---|---|---|---|---|---|---|---|---|
| DH, nm | PDI | DH, nm | PDI | DH, nm | PDI | |||
| ePC–POPG 80:20 * | L | –59.2 ± 1.4 | 111.1 ± 34.1 | 0.094 | 112.9 ± 27.1 | 0.057 | 107.3 ± 29.2 | 0.074 |
| ePC–Chol–POPG 55:25:20 * |
L-Chol | –60.1 ± 0.6 | ND | ND | ND | ND | ND | ND |
| ePC–POPG–aC-PC 70:20:10 * |
L-aC-PC10 | –49.5 ± 0.8 | 121.1 ± 34.0 | 0.079 | 159.3 ± 70.6 | 0.196 | 147.7 ± 52.7 | 0.127 |
| ePC–POPG–aC-PC 55:20:25 * |
L-aC-PC25 | –50.2 ± 0.8 | 109.9 ± 22.6 | 0.042 | 111.5 ± 31.11 | 0.078 | 126.9 ± 28.4 | 0.050 |
| ePC–Chol–POPG–aC-PC 45:25:20:10 ** |
L-Chol-aC-PC10 | –54.9 ± 0.5 | 97.4 ± 21.3 | 0.055 | 105.7 ± 28.1 | 0.071 | ND | ND |
* Data obtained using Nanosizer ZS (Malvern Panalytical, Ltd., Malvern, UK), Z-average ± PDI width and ZP average ± SE are reported. ** Data obtained using 90Plus (Brookhaven Instruments) analyzer, average diameter ± half-height half-width are reported. ND, not determined.