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. 2022 Jan 20;23(3):1143. doi: 10.3390/ijms23031143

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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sst5TMD4 overexpression induces phosphorylation of key oncogenic pathway components in a cell line dependent manner. (A) Heatmap showing the logarithm of fold-change mean corresponding to each signaling pathway comparing sst5TMD4-transfected (overexpression) vs. mock-transfected cells (Left panel); Membranes showing the spots quantified in order to study the phosphorylation level of 55 proteins under different experimental conditions (sst5TMD4-transfected vs. mock-transfected cells; Right panel). (B,C) Circle plot with Log2 (Fold Change; FC) of each measured protein in the phosphoarray comparing sst5TMD4-transfected (overexpression) vs. mock-transfected cells [U-87 MG (B) and U-118 MG (C)]. (D–H) Individual phosphorylation protein level after sst5TMD4 overexpression vs. the control condition in both GBM cell lines [threshold: log2 (FC) = ± 0.2; pointed line].