Table 2.
Results of human controlled clinical trials for cell-based periodontal regenerative therapy.
| Author (Year) | Cell Type | Sample Size | Experimental Groups | Observation Period | Statistical Significance |
|---|---|---|---|---|---|
| Dhote et al. (2015) [59] |
Allogenic Cord MSC |
14 patients 24 defects |
Control: open flap debridement Test: beta-TCP + rhPDGF-BB + cells |
6 months | ◯ (CAL gain, PPD reduction, radiographic bone fill) |
| Chen et al. (2016) [60] |
Autologous PDLSC | Total 41 Control 21 Test 20 |
Control: GTR +BioOss Test: GTR + PDLSC + BioOss |
3, 6, 12 months | × (CAL, PPD, GR) |
| Ferrarotti et al. (2018) [61] |
Autologous DPSC | Total 29 Control 14 Test 15 |
Control: Collagen sponge Test: Collagen sponge + cells |
6, 12 months | ◯ (CAL gain, PPD reduction, radiographic bone defect fill) |
| Sánchez et al. (2020) [62] |
Autologous PDL-MSC | Total 19 Control 9 Test 10 |
Control: Xenogeneic bone substitute Test: Xenogeneic bone substitute + cells |
6, 9, 12 months | × (Test group showed greater CAL gain and PPD reduction than control with no statistical significance) |
| Apatzidou et al. (2021) [63] |
Autologous BM-MSC | Total 27 Each group 9 |
Group A: collagen + fibrin/platelet lysate + cells Group B: collagen + fibrin/platelet lysate Group C: Flap surgery |
12 months | × (All group showed similar results) |
MSC: mesenchymal stem cells, PDLSC: periodontal ligament stem cells, PDL: periodontal ligament, BM: bone marrow, TCP: tricalcium phosphate, PDGF: platelet-derived growth factor, GTR: guided tissue regeneration, CAL: clinical attachment level, PPD: probing pocket depth, GR: gingival recession.