Figure 4.

Comparison of the circulating exhausted (PD-1⁺OX40⁻) and activated (OX40⁺PD-1⁻) T cells in discharged (blue) and deceased (red) coronavirus disease 2019 (COVID-19) patients between the first and the last determination in the ICU. (A) CD4⁺PD-1⁺OX40⁻ T cells. (B) CD8⁺PD-1⁺OX40⁻ T cells. (C) Total PD-1⁺OX40⁻ T cells. (D) CD4⁺OX40⁺PD-1⁻ T cells. (E) CD8⁺OX40⁺PD-1⁻ T cells. (F) Total OX40⁺PD-1⁻ T cells. All data shown are the median and 95% confidence intervals of cells per microliter. ^#p ≤ 0.05m, ^##p ≤ 0.01 comparing opposite groups, respectively; *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 compared with ICU admission, respectively.