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. 2022 Jan 20;23(3):1101. doi: 10.3390/ijms23031101

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of the pentosidine, methylglyoxal, glyoxalase 1 activity, and advanced glycation end product (AGE) production in HDF cells before and after the treatment. Pentosidine, methylglyoxal, and AGE production was induced by 10 mJ/cm² of UVB irradiation (A,B,D). The induced pentosidine, methylglyoxal, and AGE concentrations were significantly reduced after treatment with 1000 μg/mL of EverCTP^TM (NEWTREE Co., Ltd., Seoul, Korea). Glyoxalase 1 activity was reduced by 10 mJ/cm² of UVB irradiation, and the reduced glyoxalase 1 activity was significantly increased with treatment of 1000 μg/mL of EverCTP^TM (C); *** p < 0.005, independent samples t-test. HDF, human dermal fibroblast; ultraviolet-B; UV, ultraviolet.