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. 2022 Jan 21;23(3):1192. doi: 10.3390/ijms23031192

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Fentanyl (FE) treatment started after the induction of L-ornithine (LO) acute pancreatitis (AP) reduces disease severity. (A) Representative histopathological images of pancreatic tissues of the treatment groups. Bar charts show the extent of pancreatic (B) necrosis, (C) leukocyte infiltration, (D) water content, (E) interleukin-1β (IL-1β) concentration, (F) myeloperoxidase (MPO) activity, and (G) serum amylase activity measurements. Values represent mean with standard error, n = 10–18. Two-way ANOVA was performed followed by the Holm–Sidak post hoc test. * p < 0.05; ** p < 0.001.