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. 2022 Jan 21;23(3):1209. doi: 10.3390/ijms23031209

Table 1.

List of PDE-4-I named in the manuscript with human clinical trials numbers (data collected from www.clinicaltrial.gov, accessed on 30 December 2021).

Name Disease Clinical Trials
Apremilast Psoriasis, Psoriasis-arthritis, Discoid Lupus Erythematosus, Atopic Dermatitis, Lichen Planus of Vulva, Acne Conglobata NCT00708916, NCT01393158, NCT03656666, NCT04161456, NCT01307423, NCT01212770, NCT01212757, NCT01172938
CDP840 none
CHF6001 COPD, Asthma NCT02986321, NCT04756960, NCT04739774, NCT03004495, NCT03004417, NCT01689571, NCT04636801, NCT04636814
Cilomilast Pulmonary Disease, Chronic Obstructive NCT00103922
Crisaborole Atopic Dermatitis; Eczema; Seborrheic Dermatitis; Alopecia Areata; Stasis Dermatitis; Psoriasis NCT03233529, NCT04498403, NCT04040192, NCT03832010, NCT03539601, NCT03233529, NCT04214197, NCT04360187, NCT03567980, NCT03868098, NCT04299503, NCT04091087, NCT03760042, NCT03356977, NCT03260595, NCT04008784 NCT03954158, NCT01652885, NCT04800185, NCT01300052, NCT01602341, NCT02118792, NCT02118766, NCT01301508, NCT04194814, NCT03770858, NCT03645057, NCT00759161, NCT00755196, NCT01029405, NCT01258088, NCT00763204, NCT00762658
Denbufylline none
DRM02 Rosacea, Atopic Dermatitis, Psoriasis NCT01993446, NCT01993420, NCT01993433
E6005/RVT-501 none
Ibudilast Alcohol Use Disorders, Methamphetamine-dependence, Medication Overuse Headache, Migraine Headache, Amyotrophic Lateral Sclerosis, Opioid Abuse, Glioblastoma, Amyotrophic Lateral Sclerosis, Pneumonia, Vira, Multiple Sclerosis, Myelopathy, Spinal Cord Diseases NCT02025998, NCT03594435, NCT03341078, NCT01317992, NCT01389193, NCT01860807, NCT04057898, NCT01740414, NCT03782415, NCT02238626, NCT03489850, NCT01217970, NCT02714036, NCT04054206, NCT03533387, NCT04429555, NCT01982942, NCT04631471
LEO 29102 Psoriasis Vulgaris, Atopic Dermatitis NCT00891709, NCT01447758, NCT01005823, NCT00958516, NCT01037881, NCT00875277, NCT01466478, NCT01423656
Nitraquazone none
OPA-15406/MM36. Atopic Dermatitis NCT02914548, NCT03908970, NCT03911401, NCT03961529, NCT03018691, NCT02334787, NCT02068352, NCT01702181
Piclamilast none
Rolipram NCT00369798,NCT01215552,NCT00250172, NCT01602900, NCT00011375
Roflumilast COPD, Blood sugar and Insulin, Major Depressive Disorder, Asthma, post Stroke, Obesity, Alzheimer’s Disease, Bronchiectasis, Non-cystic Fibrosis, Dermatitis, Diabetes Mellitus Type 2, Respiratory Distress Syndrome, Psoriasis, Obesity, Polycystic Ovary Syndrome, Dementia, Mild Cognitive Impairment, Sarcoidosis, Diabetic Nephropathies, Lymphoma (B-Cell), Schizophrenia, Atopic Dermatitis, Nonalcoholic Steatohepatitis, Major Depressive Disorder, Allergy, Seborrheic Dermatitis, NCT04108377,NCT02363335, NCT04751071,NCT00246935,NCT00242294, NCT00242307, NCT00246922,NCT04854811, NCT01862029,NCT02835716, NCT04636814, NCT02386761, NCT01703052, NCT02119247, NCT01730404, NCT02986321, NCT02018432, NCT04322929, NCT01745848, NCT01354782, NCT00424268, NCT00430729, NCT01365533, NCT01329029, NCT00746382, NCT04069312, NCT04122547, NCT01630200, NCT01509677, NCT01973998, NCT00163475, NCT02068456, NCT01443845, NCT00076076, NCT00076089, NCT00313209, NCT01140542, NCT04744090, NCT03428334, NCT01473758, NCT04549870, NCT02037672, NCT00746434, NCT00297102, NCT00297115, NCT00242320, NCT01433666, NCT00062582, NCT00163527, NCT04658654, NCT01830959, NCT04090294, NCT03381573, NCT02451540, NCT02187250, NCT03988816, NCT01313494, NCT04755946, NCT02097992, NCT01849341, NCT04369547, NCT04800172, NCT03458546, NCT03073798, NCT01765192, NCT02079844, NCT01701934, NCT01856764, NCT00940329, NCT02015767, NCT01888952, NCT02165826, NCT01664624, NCT01595750, NCT02051335, NCT02187926, NCT00073177, NCT00108823, NCT01572948, NCT01480661, NCT02671942, NCT04636814, NCT01285180, NCT05028582, NCT01285167, NCT01580748, NCT04286607, NCT04773587, NCT04211363, NCT04211389, NCT04973228, NCT04773600, NCT04845620, NCT04804605
Ro 20-1724 none
RP 73401 none
Xanthine nucleus none
Zardaverine none