Figure 8.

Pathways’ analysis plot of the disturbed metabolic pathways in dogs infected with B. canis compared to healthy dogs (a). Glutathione metabolism, as well as alanine, aspartate, and glutamate metabolism, glyoxylate and dicarboxylate metabolism, cysteine and methionine metabolism, arginine and proline metabolism, arginine biosynthesis, citrate cycle and phenylalanine, tyrosine, and tryptophan biosynthesis were significant pathways with a p value of <0.05 and impact of >0.1. Biological pathways network and summary plot derived from metabolite set enrichment analysis for prediction of pathways associated serum metabolites sets (b). The colors and the bar length represent the metabolites with different levels of significance for enrichment analysis.