Table 1.

List of identified and significantly changed metabolites in serum of dogs infected with B. canis versus healthy dogs obtained using the untargeted LC-MS metabolomics approach.

Metabolite	Peak ID	Mass	RT(s)	p-Value	Log2 (FC)
Inosine	1280	267.0736	591.68	1.74 × 10−10	4.62
Hypoxanthine	70	137.0458	567.72	3.00 × 10−6	2.95
Choline phosphate	352	184.0734	714.56	8.90 × 10−5	2.29
Imidazole-4-acetate	169	127.0502	624.14	6.69 × 10−4	1.81
Cystine	407	241.031	771.48	1.59 × 10−4	1.54
Citrate	848	191.02	828.92	5.74 × 10−4	0.95
Citrulline	73	176.103	764.51	1.94 × 10−5	0.91
Methionine	51	150.0584	610.06	1.50 × 10-4	0.76
Glycerol-3-phosphate	1657	171.0066	713.52	3.26 × 10−3	0.62
Proline	1004	114.0561	659.98	2.94 × 10−3	0.58
Pyroglutamic acid	951	128.0354	575.74	3.86 × 10−4	−0.70
Phenylalanine	54	166.0863	551.14	9.88 × 10−7	−1.13
Pyruvate	1209	87.0088	501.48	3.05 × 10−5	−1.15
Kynurenine	199	209.0921	580.41	5.04 × 10−9	−1.72