Figure 6.

Ribbon representation of open and closed conformations of WT-RMPK (A) and of MtbPK (B). According to the movement of the upper B domain over the central A domain of WT-RMPK, panels show the superposition of open/inactive (cyan) and closed/active (green) conformers. In both conformers, the distances between O of T120 to O S76 or O of L75 to S37 are shown. Panel A was constructed from the coordinates of PDB 1A49 subunit A (green) with its active site completely occupied (oxalate, Mg²⁺, -Mg-ATP, and K⁺) (closed conformation) and subunit B (cyan) with its active site partially occupied (oxalate, Mg²⁺and K⁺) (open conformation) [17]. Panel B was constructed from the coordinates of PDB 5WS9 subunit A (green) with its active site completely occupied (oxalate, Mg²⁺ Mg-ATP, and K⁺) and of PDB 5WRP subunit A (cyan) with its active site empty [18]. This figure was built using the program PYMOL v 2.3.1.