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. 2022 Feb 1;23(3):1696. doi: 10.3390/ijms23031696

Figure 1.

Figure 1

Cassiaside C inhibits M1 macrophage polarization. (A) Chemical structure of Cassiaside C. (B,C) Effects of Cassiaside C on iNOS mRNA expressions in LPS/IFN-γ-stimulated Raw264.7 cells and PMs. (D,E) Effects of Cassiaside C on levels of iNOS, CD80, CD86, TNF-α, and COX-2 in LPS/IFN-γ-stimulated Raw264.7 cells and PMs. (F,G) Effects of Cassiaside C on NO concentrations in LPS/IFN-γ-stimulated Raw264.7 cells and PMs. (H,I) Effects of Cassiaside C on cellular viability in LPS/IFN-γ-stimulated Raw264.7 and PM cells. Data are expressed as the mean ± SEM (n = 3 technical replicates). N.S., not significant; * p < 0.05, ** p < 0.01, and *** p < 0.001. PM, peritoneal macrophages.