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. 2022 Feb 1;23(3):1696. doi: 10.3390/ijms23031696

Figure 2.

Figure 2

Cassiaside C suppresses LPS/IFN-γ-stimulated pro-inflammatory cytokine expression and secretion by macrophages. (A,B) Effects of Cassiaside C on TNF-α, IL-β, IL-6, and MCP-1 mRNA expression in LPS/IFN-γ-stimulated Raw264.7 cells and PMs. (C,D) Effects of Cassiaside C on secretion of TNF-α, IL-β, and IL-6 in LPS/IFN-γ-stimulated Raw264.7 cells and PMs. (E,F) Effects of Cassiaside C on phosphorylated NF-κB in LPS/IFN-γ-stimulated Raw264.7 cells and PMs. Data are expressed as the mean ± SEM (n = 3 technical replicates). * p < 0.05, ** p < 0.01, and *** p < 0.001. PM, peritoneal macrophages.