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. 2022 Feb 1;23(3):1696. doi: 10.3390/ijms23031696

Figure 4.

Figure 4

Cassiaside C suppresses glycolysis but increases mitochondrial respiration in LPS/IFN-γ-stimulated macrophages. (A–E) The ECAR in LPS/IFN-γ-stimulated macrophages. ECAR kinetic traces (A,B), glycolytic capacity and reserve (C,D), and lactate levels (E) in LPS/IFN-γ-stimulated macrophages treated with or without Cassiaside C. (F–I) OCR kinetic traces (F) and rates of basal (G), maximal (H), and ATP-linked (I) respiration in LPS/IFN-γ-stimulated macrophages treated with or without Cassiaside C. Data are expressed as the mean ± SEM (n = 3 technical replicates). * p < 0.05, ** p < 0.01, and *** p < 0.001. 2-DG, 2-deoxyglucose 2-Dexyo glucose. AA, antimycin A/Rot, rotenone.