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Schematic representation of Doxorubicin (DOX)-induced apoptosis pathway. DOX, doxorubicin; ROS, reactive oxygen species; MAPK, mitogen-activated protein kinase; JNK, Jun amino terminal kinase; ERK, extracellular signal-regulated kinase; NAC, N-acetylcysteine; TopII, opoisomerase II; PGC-1α, PPARG coactivator 1α; GPX1, glutathione peroxidase 1; HDAC, histone deacetylase; GATA4, GATA binding protein 4.
