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Schematic representation of Doxorubicin (DOX)-induced ferroptosis pathway. DOX, doxorubicin; Tf, transferrin; GSH, glutathione; GSSG, oxidized glutathione; GPX4, glutathione and glutathione peroxidase 4; FSP1, ferroptosis suppressor protein 1; CHAC1, ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1; Nrf2, Nuclear factor erythroid 2-related factor 2; KEAP1, Kelch-like ECH-associated protein 1; ABCB8, ATP-binding cassette transporter 8; CoQ10, coenzyme Q10.
