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. 2022 Jan 27;23(3):1475. doi: 10.3390/ijms23031475

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Bone morphologic protein 9 (BMP9) expression is correlated with the expression of angiogenesis-associated factors. (A) Correlation between BMP9 (GDF2) and VEGFR2 (KDR) gene expression. (B) Correlation between BMP9 (GDF2) and HIF-1α (HIF1A) gene expression. (C) Representative immunohistochemistry (IHC) staining images of BMP9/HIF-1α high (upper panel) and BMP9/HIF-1α low (lower panel) surgically resected hepatocellular carcinoma (HCC) tissue specimens. (D) Correlation of BMP9 and HIF-1α in HCC patients. The p value was calculated by the chi-squared test.