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. 2022 Jan 28;23(3):1542. doi: 10.3390/ijms23031542

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Glomerulonephritis characterized by a fibrous structure formation (crescent) in renal corpuscle. Glomerular PECs (cytokeratin+) are the main actors, infiltrating cells such as macrophages (CD68+) in crescent formation during rapid progressive glomerulonephritis/crescentic glomerulonephritis (RPGN/CGN). Activated PECs (CD44+/cytokeratin-) invade the glomerular urinary space and obstruct the urinary space. PEC “activation” implies a phenotypic change that promotes their abnormal proliferation and their migration towards the urinary space of renal corpuscles.