Figure 5.

(A) Tumor development according to the M1 or M2 TAM phenotype in the TME: the M1 phenotype is induced by inflammatory molecules (yellow) and M2 phenotype by anti-inflammatory molecules (red). M1 TAM promote the killing of cancer cells and M2 TAM produce factors promoting tumor development. (B) Reprogramming of M2 TAM with: (i) monoclonal antibodies (mAb) or peptides targeting specific membranes receptors; (ii) small molecules targeting specific membrane proteins or penetrating into TAM; (iii) nanoparticles; (iv) other systems.