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. 2022 Feb 1;23(3):1707. doi: 10.3390/ijms23031707

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Differential expression of various phosphorylated proteins associated with different signalling pathways. (A) Images of proteome profiler membranes showing differential expression of the phosphorylated proteins involved in MAPK, AKT, JAK-STAT, NF-ĸB and TGFβ signalling pathway after 50 μM of fisetin treatment for 48 h in comparison with the DMSO control. (B) Graphical presentation of downregulated expression of different proteins in the aforementioned pathways, while the expression of P53 (p-ser241) and P27 (p-Thr198), p38(P-Thr180/Tyr-182) were upregulated. Differential expression is shown as fold change. Data are presented as the mean ± standard deviation of three independent experiments *** p < 0.001.