Table 2.
Table showing fisetin-mediated modulation of various signalling pathways by altered expression of different genes and phosphorylated proteins.
| Hall Mark | Molecular Target | Transcript Expression | Protein Expression | ||
|---|---|---|---|---|---|
| Upregulation | Downregulation | Upregulation | Downregulation | ||
| Pathways:Anti-proliferation, anti-inflammation and apoptosis-inducing pathway | MAPK | MAPK1, MAK14, MAP2K1, MAP2K6, ELK 1 | p38 (P-Thr180/Tyr182) and P53 (P-Ser15) | RSK1 (P-Ser380) and Raf-1 (P-Ser301) | |
| AKT/MTPR/PI3K | AKT2, MTOR, PIK3C2B, PIK3CB. | p27 (P-Thr198) | GSK3a (p-ser21), GSK3b (p-ser9), MTOR (p-ser2448), PRAS 40 (p-Ther246), BAD (p-ser112), PTEN (p-ser380), AKT (p-ser473), AMPKa (P-Thr172), RPS6 (P-Ser235/236), and 4E-BP1 (P-Thr36). | ||
| JAK-STAT and NF-kB | Src (P-Tyr419), STAT1 (P-Ser727), STAT2 (P-Tyr689), STAT3 (P-Tyr705), STAT5 (P-Tyr694), TYK2 (P-Tyr1054), HDAC4 (P-Ser632), NF-kB (P-Ser536), TAK1 (P-Ser412) and TBK1 (P-Ser172). | ||||