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Effect of LCZ696 and valsartan on AGEs accumulation (A) and RAGE expressions (B) in cardiac tissues. The data are expressed as mean ± SEM (n = 6). Statistical analysis was conducted by one-way ANOVA followed by Student–Newman–Keuls as a post-hoc test. The levels of significance were determined as: * p < 0.001, # p < 0.05, ## p < 0.001, + p < 0.05, and ++ p < 0.01. * DCM vs. Control, # LCZ696 and valsartan vs. DCM, + LCZ696 vs. valsartan.
