Figure 3.

Influence of PSB–CB–27 (A–D) and O–1918 (A,C) on the vasorelaxation induced by NAGly (A,C) and Abn–CBD (B,D) in endothelium-intact isolated human pulmonary arteries. Concentration-response curves (mean ± SEM of 7–13 tissue samples) and representative original traces of the NAGly–(A,C) or Abn–CBD–(B,D) induced relaxation (also in the presence of PSB–CB–27 or O–1918) are shown in the upper and lower panels, respectively. In (A,B), the results are expressed as the percentage relaxation of the isometric contraction induced by U46619. See Table 1 and Table 2 for the statistical analysis and for potencies. CONTROL refers to the effects of the agonists in the absence of the particular antagonist. The effects of increasing concentrations of ethanol (max. < 0.6%), given repeatedly, are shown as well (B,D). Arrows show the moment of application of a particular concentration of NAGly or Abn–CBD.