Table 1:
Clinicopathological features in tumors with and without tumor spread through air spaces (STAS)
| Clinicopathological characteristic of the resections | STAS (−) tumors N=57 n (%) | STAS (+) tumors N=43 n (%) | p-value 1) | |
|---|---|---|---|---|
| Age at surgery (years; mean ± SD) | 69.9 ± 9.8 | 67.7 ± 10.5 | 0.3 | |
| Gender | Female / Male | 42 (74) / 15 (26) | 25 (54) / 18 (42) | 0.1 |
| Tumor size | Entire size (cm; mean ± SD) | 1.5 ± 0.6 | 1.7 ± 0.6 | 0.04 |
| Invasive size (cm; mean ± SD) | 0.8 ± 0.7 | 1.5 ± 0.6 | <0.0001 | |
| Type of resection | 0.5 | |||
| Lobectomy and other anatomical resections | 13 (23) | 15 (35) | ||
| Wedge resection + completion lobectomy | 9 (16) | 6 (14) | ||
| Segmentectomy | 7 (12) | 3 (7.0) | ||
| Wedge resection | 28 (49) | 19 (44) | ||
| Morphologic patterns | Predominant histologic pattern | <0.0001 | ||
| Lepidic | 29 (51) | 3 (7.0) | ||
| Acinar | 16 (28) | 11 (25.5) | ||
| Papillary | 3 (5.3) | 5 (11.5) | ||
| Micropapillary | 2 (3.5) | 8 (19) | ||
| Solid | 2 (3.5) | 9 (21) | ||
| Complex glands2) | 5 (8.8) | 7 (16) | ||
| Lepidic ≥ 5% | 43 (75) | 9 (21) | <0.0001 | |
| Micropapillary ≥ 5% | 5 (8.8) | 17 (40) | 0.0006 | |
| Solid ≥ 5% | 10 (18) | 22 (51) | 0.0008 | |
| Complex glands ≥ 5% | 13 (23) | 24 (56) | 0.0009 | |
| Other histological features | Tumor grade | ≤0.0001 | ||
| Grade 1 | 27 (48) | 2 (4.7) | ||
| Grade 2 | 15 (26) | 6 (14) | ||
| Grade 3 | 15 (26) | 35 (81) | ||
| Lymphatic vessel invasion+ | 7 (12) | 11 (26) | 0.01 | |
| Blood vessel invasion+ | 5 (8.8) | 4 (9.3) | 0.2 | |
| Pleural invasion + | 2 (3.5) | 4 (9.3) | 0.4 | |
| Tumor necrosis + | 8 (14) | 13 (30) | 0.08 | |
| Mutational status | EGFR (n=95) | 17 (30) | 7 (16) | 0.1 |
| KRAS (n=97) | 11 (19) | 20 (43) | 0.002 | |
| ALK rearrangement (n=94) | 1 (1.8) | 1 (2.3) | 0.2 | |
Data are n unless otherwise specified
1)
p-values were calculated by the t-test, and the chi-square test
2)
including cribriform pattern