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Cluster differentiation of the currently known PPGL susceptibility genes.
| Germline and Somatic | Exclusively Somatic | ||
|---|---|---|---|
| Cluster 1: Pseudohypoxic cluster | Cluster 1A | SDHA/B/C/D/AF2, FH, MDH2, IDH3B, GOT2, DLST, SLC25A11 | IDH1/2 |
| Cluster 1B | EGLN1, VHL | EPAS1 | |
| Cluster 2: Kinase signalling cluster | RET, MERTK, MET, NF1, MAX, TMEM127 | FGFR1, HRAS, BRAF | |
| Cluster 3: Wnt signaling cluster | - | CSDE1, UBTF-MAML3 | |
