Table 2.
Reference | Methods | Omics | Key Findings |
---|---|---|---|
Gao et al. [47] | bioinformatics, immunohistochemistry, cell-based assay, Western blot | genomics, transcriptomics, epigenomics, proteomics | TMEFF2 as target for early diagnosis and EC treatment |
Geng et al. [48] | bioinformatics, cell-based assay, qPCR, Western blot | genomics, transcriptomics, proteomics | RNF183 as prognostic and early diagnostic indicator for EC |
Geng et al. [49] | bioinformatics, cell-based assay, qPCR | genomics, transcriptomics, epigenomics proteomics | ZBTB7A as prognostic biomarker for EC |
Li et al. [50] | bioinformatics, cell-based assay, qRT-PCR, Western blot | genomics, transcriptomics, epigenomics proteomics | BTG1 as prognostic biomarker for EC |
Wan et al. [51] | bioinformatics, immunohistochemistry, cell-based assay, qPCR | genomics, transcriptomics, proteomics | HOXB9 is correlated with EC cell migration and promotes its progression |
Zhang et al. [52] | immunohistochemistry, cell-based assay, qRT-PCR, Western blot | genomics, transcriptomics, proteomics | TTK as therapeutic target for EC |
Zhang et al. [53] | bioinformatics, immunohistochemistry, cell-based assay, qPCR | genomics, transcriptomics, proteomics | ARF/ARL family genes as prognostic biomarkers for EC |
Zou et al. [54] | bioinformatics, immunohistochemistry | genomics, transcriptomics, proteomics | LGR5, SST, ZNF558, and PTGDS participate in the development of EC; PTGDS as biomarker and therapeutic target for EC |
TMEFF2, tomoregulin-2; RNF183, ring finger protein 183; ZBTB7A, zinc finger and BTB domain-containing protein 7A; BTG1, BTG anti-proliferation factor 1; HOXB9, homeobox B9; TTK, TTK protein kinase; ARF/ARL, ADP-ribosylation factor/ARF-like protein; LGR5, leucine-rich repeat-containing G-protein coupled receptor 5; SST, somatostatin; ZNF558, zinc finger protein 558; PTGDS, prostaglandin D2 synthase.