Table 2.
CM miRNA signatures as biomarkers of survival.
| miRNA Signature | Significance | Datasets | Samples | Reference |
|---|---|---|---|---|
| miR-31-5p, miR-21-5p, miR-211-5p, miR-125a-5p, miR-125b-5p and miR-100-5p (miRNA ratios) | distinction of melanomas from nevi |
FFPE phs001550.v2.p1 (miRNASeq) | 41 nevi and 41 melanomas | [37] |
| miR-155-5p, miR-9-5p, miR-142-5p, miR-19a-3p, miR-134-5p, miR-301a-3p, miR-205-5p, miR-203a-3p, miR-27b-3p, miR-218-5p, and miR-23b-3p | FFPE (microarray) |
5 cutaneous nevi and 27 primary melanomas | [38] | |
| miR-142-5p, miR-550a, miR-1826, and miR-1201 |
GSE62370 (microarray) |
9 congenital nevi and 92 primary melanomas | [39] | |
| miR-205, miR-203, miR-200a-c, and miR-141 | distinction of metastatic from primary melanomas | TCGA (miRNASeq) |
97 primary and 350 metastatic melanomas | [40] |
| miR-150-5p, miR-15b-5p, miR-16-5p, and miR-374b-3p | prediction of brain metastases |
IMCG GSE62372 (microarray) |
256 primary melanomas | [41] |
| miR-125b, miR-200c and miR-205 | prediction of overall survival |
FF (RT-qPCR) | 65 primary and 67 metastatic melanomas | [51] |
| miR-202, miR-206, miR-3681, miR-122 and miR-1246 | TCGA (miRNASeq) |
448 melanomas | [52] | |
| miR-16, miR-211, miR-4487, miR-4706, miR-4731, miR-509-3p and miR-509-5p | FFPE (RT-qPCR) |
86 melanomas | [53] | |
| miR-497, miR-145, miR-342-5p, miR-150, miR-155 and miR-455-5p | prediction of post-recurrence survival |
FFPE (microarray) |
59 melanomas | [54] |
| miR-25, miR-204, miR-211, miR-510 and miR-513c | prognostic biomarker in cutaneous melanoma |
GSE35579 (microarray) |
11 benign nevi and 41 melanomas | [55] |
| miR-10b | FF (microarray) | 20 non-metastasizing and 20 metastasizing primary melanomas |
[56] | |
| miR-338, let-7, miR-365, miR-191, miR-193b-3p and miR-193a-3p | FF, GSE19387 (microarray) | 32 samples from regional lymph node metastases | [57] | |
| miR-150-5p, miR-142-3p and miR-142-5p | FF (microarray) | 84 samples from lymph node metastases | [58] | |
| miR-21-5p, miR-424-5p and let-7b | associated with invasive and aggressive phenotype |
FF, GSE36236 (miRNASeq) | 12 normal skin, 13 common nevi, 17 dysplastic nevi, 45 melanomas in situ and 80 primary cutaneous melanomas | [59] |
FFPE: Formalin-Fixed Paraffin-Embedded; FF: Fresh Frozen; IMCG: Interdisciplinary Melanoma Cooperative Group; RT-qPCR: reverse transcription quantitative Real time PCR.