Table 2.

Summary of apoptotic proteins and their role in oral cancer.

Protein	Role in Oral Cancer	Reference
Granzyme B	Cytotoxic T lymphocyte mediated tumour cell apoptosis	Zhu et al. [90]
Perforin	Takes part in NK cell mediated oral cancer cell destruction	Hadler-Olsen et al. [91]
FasL	Mediator of immune privilege in OSCC	Fang et al. [92]
Fas (CD95)	Considered a prognostic marker of OSCC	Peter et al. [93]
TNF-α	Promotes oral cancer growth and pain	Salvo et al. [94]
TNFR1 (CD120a)	Related to oral cancer pain and inflammation	Scheff et al. [95]
FADD	Prognostic implication in OSCC	Gonzales-Moles et al. [96]
Apaf1	Helps in the formation of apoptosome	Dwivedi et al. [97]
Bcl-2	Altered expression results in an increase in malignant transformation potential	Juneja et al. [98]
Bcl-2a1 (Bfl-1) and Cytochrome C	Promotes apoptosis in OSCC	Zheng et al. [99]
Mcl-1	Overexpression of anti-apoptotic factor Mcl-1 leads to progression of OSCC	Sulkshane et al. [100]
Bcl-xL	Causes resistance to chemotherapeutic drugs	Alam et al. [101]
Bcl-w	Cooperates with oncogene activation in the development and progression of OSCC	Hartman et al. [102]
BH3	Anti-anti-apoptotic functions in OSCC	Carter et al. [103]