Figure 3.
AHR modulates ALI in vivo via CYP1A enzymes. AHR is expressed in lungs and liver. In hyperoxic lung injury animal models, AHR deficiency potentiates the symptoms, which may be associated with AHR-regulated genes, such as CYP1A1/2, in these tissues. AHR-regulated genes may also alleviate LPS-induced lung injury. The CYP1A enzymes attenuate lung injury by detoxifying lipid hydroperoxides, such as F2-isoprostanes [129,152,153].